COLEUS
FORSKOHLII

Product data


Forskolin

Product Forskolin
Product No. 600-03-001
Batch No. F01100pl
Origin Isolated from cultivated plant Coleus forskohlii
CAS Number 66575-29-9
Molecular formula C22H34O7
Molecular weight 410.5 Da
Form White solid
Storage Stored at +4°C stable for minimum one year
Decomposition Data in progress
Solubility Good soluble in methanol, ethanol, DMSO, acetonitril
Description Forskolin is a labdane diterpene with great impact on cellular processes governed by cyclic adenosine monophosphate. The basic mechanism of action of forskolin is the activation of adenylate cyclase, which increases (cAMP) in cells. The physiological and biochemical effects of a raised intracellular cAMP level include: inhibition of platelet activation and degranulation; inhibition of mast cell degranulation and histamine release; increased force of contraction of heart muscle; relaxation of the arteries and other smooth muscles; increased insulin secretion; increased thyroid function; and increased lipolysis.

 

Moreover, specifically forskolin has been shown to inhibit a number of membrane transport proteins and channel proteins through a mechanism that does not involve the production of cAMP.


Test/Analysis Specifications Results
Appearance white powder
Purity HPLC C18: 202 nm > 99 %
Solubility Pyridine, Ethanol, Methanol, Acetonitril, Aceton, and other confirms

Identification 1H-NMR, UV/VIS Spectroscopy (data not shown)
Purity Minimum 96 % (HPLC), batch F01100pl (Figure 1)


Figure 1: LC RP C18 Forskolin F0110pl, detection: 202 nm, integration: 202 nm: ret. 6.38, >96 %

 
CAS No: 66575-29-9
CF1
C22H34O7
Forskolin
CAS 66575-29-9
FS

 

 




Chemical structure of Forskolin



Coleus forskohlii



7-Deacetyl Forskolin

 


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