Forskolin
| Product |
Forskolin |
| Product No. |
600-03-001 |
| Batch No. |
F01100pl |
| Origin |
Isolated from cultivated plant Coleus forskohlii |
| CAS Number |
66575-29-9 |
| Molecular formula |
C22H34O7 |
| Molecular weight |
410.5 Da |
| Form |
White solid |
| Storage |
Stored at +4°C stable for minimum one year |
| Decomposition |
Data in progress |
| Solubility |
Good soluble in methanol, ethanol, DMSO, acetonitril |
| Description |
Forskolin is a labdane diterpene with great impact on cellular processes governed by cyclic adenosine monophosphate. The basic mechanism of action of forskolin is the activation of adenylate cyclase, which increases (cAMP) in cells. The physiological and biochemical effects of a raised intracellular cAMP level include: inhibition of platelet activation and degranulation; inhibition of mast cell degranulation and histamine release; increased force of contraction of heart muscle; relaxation of the arteries and other smooth muscles; increased insulin secretion; increased thyroid function; and increased lipolysis.
Moreover, specifically forskolin has been shown to inhibit a number of membrane transport proteins and channel proteins through a mechanism that does not involve the production of cAMP. |
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| Test/Analysis |
Specifications |
Results |
| Appearance |
|
white powder |
| Purity |
HPLC C18: 202 nm |
> 99 % |
| Solubility |
Pyridine, Ethanol, Methanol, Acetonitril, Aceton, and other |
confirms |
|
| Identification |
1H-NMR, UV/VIS Spectroscopy (data not shown) |
| Purity |
Minimum 96 % (HPLC), batch F01100pl (Figure 1) |
Figure 1: LC RP C18 Forskolin F0110pl, detection: 202 nm, integration: 202 nm: ret. 6.38, >96 %
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CF1
C22H34O7
Forskolin
CAS 66575-29-9
Chemical structure of Forskolin
Coleus forskohlii
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