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FORSKOLIN |
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| Forskolin (native) | from Coleus forskohlii | ||
| Product name | Forskolin | ||
| Product number | 600-03-001 | ||
| Origin |
isolated from cultivated plant Coleus forskohlii chemical structure of native forskolin |
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| CAS Number | 66575-29-9 | ||
| Molecular formula | C22H34O7 | ||
| Molecular weight |
410.5 Da |
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| Purity |
>96 % HPLC (minimum 96 %) >>98 % HPLC on request, see figure 1 |
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Identification |
1H-NMR | ||
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Form |
white solid |
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| Storage | stored at +4°C stable for minimum one year | ||
| Decomposition | data in progress | ||
| Solubility |
good soluble in methanol, ethanol, DMSO, acetonitrile
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Description |
Forskolin is a labdane diterpene with great impact on cellular processes governed by cyclic adenosine monophosphate. The basic mechanism of action of forskolin is the activation of adenylate cyclase, which increases (cAMP) in cells. The physiological and biochemical effects of a raised intracellular cAMP level include: inhibition of platelet activation and degranulation; inhibition of mast cell degranulation and histamine release; increased force of contraction of heart muscle; relaxation of the arteries and other smooth muscles; increased insulin secretion; increased thyroid function; and increased lipolysis. Moreover, specifically forskolin has been shown to inhibit a number of membrane transport proteins and channel proteins through a mechanism that does not involve the production of cAMP. |
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