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COPTISINE |
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| Coptisine (native) | from Chelidonium majus | ||
| Product name | Coptisine | ||
| Product number | 900-006-001 | ||
| Origin |
isolated from cultivated plant Chelidonium majus chemical structure of native coptisine |
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| CAS Number | 3486-66-67 | ||
| Molecular formula | [C19H14NO4]+ | ||
| Molecular weight |
320.33 Da |
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| Purity |
>98 % HPLC (minimum 98 %), see figure 1 |
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Purity evaluation |
HPLC, NMR, see figure 2 | ||
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Form |
solid, yellowish powder |
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| Storage | stored at room temperature stable for minimum one year | ||
| Decomposition | data in progress | ||
| Solubility |
soluble in methanol, pyridine, acetonitrile, chloroform
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Description |
Coptisine is an isoquinoline alkaloid isolated from Chelidonium majus. Coptisine has been shown in vitro to be cytotoxic on human tumour colon cell lines (Colombo M.L. et al.: Farmaco 2001; 56 (5-7): 403-409.), on human hepatoma and leukaemia cell lines (Chun-Ching Lin et al.: Clinical and Experimental Pharmacology and Physiology 2004; 31(1-2): 65-69.). Coptisine shows an inhibitory effect on MAO-A activity (Jai Seup Ro et al.: Life Sciences 2001; 70 (6): 639-645.). It also shows gastric-mucous membrane protection activity (Hirano H. et al.: Biol Pharm Bull. 2001; 24 (11): 1277-1281.). Coptisine inhibits dopamine biosynthesis (Jung Soo Shin et al.: Neurochemical Research 2000; 25 (3): 363-368.). |
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